R-2487 is a targeted oral immune therapy that has the ability to induce T regulatory cell populations. R-2487 has a unique mechanism of action by which it can engage specific microbiome-associated immune pathways that regulate tolerance, and reset T regulatory deficiencies to reduce specific inflammatory cytokines that contribute to autoimmune disease. This mechanism is particularly important in the context of treating autoimmune disease. R-2487 is being developed for the treatment of Sjogren's syndrome and other autoimmune diseases.
R-3750 is an oral immune therapy that has the potential to treat the underlying basis of GI-associated inflammatory disease by inducing immune homeostasis of the intestinal tract. Importantly, R-3750 has the ability to enhancing gut barrier integrity, an important mechanism related to successfully treating inflammatory gut disease. R-3750 is based upon targeting of a key microbiome regulatory pathway know to engage immune effectors cells lining the intestinal tract. This program is being developed for the treatment of inflammatory bowel disease (IBD).
R-5780 is an orally delivered immune oncology drug candidate that engages immune pathways for the treatment of cancer. R-5780 has demonstrated pronounced ability to enhance immune checkpoint activity. This drug candidate builds upon the growing understanding of how the microbiome can promote efficacy of immune oncology drugs. Rather than building a product around natural commensals where it can be difficult to understand mechanism of action, R-5780 is a targeted drug product that engages selective immune pathways that can drive robust anti-tumor responses.